A: Absolutely. VMware, Hyper-V, and Azure are fully supported, provided the hypervisor does not oversubscribe CPU/RAM.

A newer iteration, ExchangeServerSE-x64.iso , was released in July 2025 and is also available for 64-bit systems. Core System Requirements

Paid subscribers can download various editions and historical CUs of Exchange Server 2019 from the subscriber portal. System Requirements for 64-Bit Installation