The portable version of Autodesk AutoCAD 2010 is a self-contained version of the software that can be run from a USB drive or other portable device. This version of the software is ideal for users who need to work on multiple computers or who want to take their work with them on the go.
A stable, truly "updated" portable version of AutoCAD 2010 is 99% a myth. You will spend hours downloading malware before you find a working copy.
When you see it usually means that enthusiasts or third parties have tweaked the original files to run better on modern operating systems. This might include: