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Even if your folder says v4.0.30319 , you might actually have a newer, patched version of the framework installed.
The most critical class of vulnerabilities affecting .NET 4.0 involves Remote Code Execution. These flaws allow attackers to run arbitrary code on a victim's machine without user interaction, often through malicious files or network requests.
Never skip monthly quality updates. For Windows 7/8.1/Server 2008 R2 (where .NET 4.0 is common), ensure the or Security Only update is applied. This includes the .NET servicing stack.
If your web scanner flags this header, it is likely just reading the version from the HTTP response. You can disable this header in your web.config file to reduce information leakage.