While does not have a native "Online" button within its original 2012 Flash interface, modern workarounds and the newer Repentance Plus expansion have finally brought true online multiplayer to the franchise.

The original The Binding of Isaac: Wrath of the Lamb (the 2012 Flash version) have an official online multiplayer mode . It was designed strictly as a single-player game.

is a certified roguelike classic. But there was always one thing missing... a friend to share your pain with.

You may have seen references to having online co-op. That is correct, but only for the Repentance DLC (on the Rebirth engine). In late 2023, an official online co-op beta was released for Repentance on Steam.

Many players confuse the expansions because of the name: