Given these diverse roles, selective EP4 modulators are highly sought after. This is where enters the spotlight.
| Compound | Selectivity | Metabolic Stability | Functional Profile | Carbon Link? | |----------|-------------|--------------------|--------------------|--------------| | PGE2 | Low | Poor | Full agonist | No | | L-902,688 (Pfizer) | High | Moderate | Full agonist | No | | ONO-4819 (Ono Pharma) | High | Moderate | Full agonist | No | | | Very high | Excellent | Partial agonist/antagonist | Yes | the synthetic ep 4 beta by carbon link
The beta orientation at C-9 is preserved through selective protection/deprotection sequences. Epimerization is avoided by using non-basic conditions and low-temperature reactions. Given these diverse roles, selective EP4 modulators are