Here is a comprehensive guide on how to resolve the buddha.dll error and get back to the shadows. Common Causes of the Buddha.dll Error
Select and then add the game folder to your antivirus exclusion list to prevent it from being deleted again.
If the file is completely gone, temporarily disable your antivirus "Real-time protection," re-extract the portable game files, and then add the folder to your exclusion list before turning protection back on.
If you’re trying to run the portable version of Hitman Absolution and are greeted by an error message stating that or was not found, you aren't alone. This is one of the most common issues with this specific release of the game.